U.S. Plaque Modification Devices Market Revenue & Market Analysis, 2026-2035

The National Institute of Dental and Craniofacial Research (NIDCR) states that roughly 42% of American adults aged 30 and above suffer from periodontitis, impacting around 2 out of 5 adults. The significant occurrence of periodontal disease, heightened focus on controlling plaque and calculus, rising interest in minimally invasive periodontal therapies, and improvements in ultrasonic, laser, and other plaque-removal technologies are propelling the expansion of the U.S. plaque modification devices market.

The U.S. plaque modification devices market has experienced consistent historical growth, driven by the growing incidence of cardiovascular and peripheral artery diseases, an aging demographic, and a greater acceptance of minimally invasive endovascular techniques. For instance, in 2023, Abbott finalized its acquisition of Cardiovascular Systems, Inc. (CSI), integrating CSI’s atherectomy technologies for managing complex coronary and peripheral artery disease into Abbott’s vascular-device lineup.

The market is projected to sustain robust growth, propelled by enhanced treatment of complex and calcified lesions, innovations in plaque-modification technologies, and a rising inclination towards catheter-based interventions. For instance, in May 2026, Johnson & Johnson released the Shockwave C2 Aero Coronary IVL Catheter globally, offering improved deliverability, lesion-crossing, and balloon-repositioning features for addressing calcified coronary artery disease. The launch demonstrates ongoing investment in sophisticated calcium-modification technologies that can enhance expansion in plaque-modification procedures.

U.S. Plaque Modification Devices Market Overview

Base Year Market Size (2025): USD 832.59 Million

CAGR: 8.3%

Forecast Year Market Size (2035): USD 1,839.33 Million

Major Players:

• Abbott Laboratories

• Boston Scientific Corporation

• Becton, Dickinson and Company (BD)

• Medtronic plc

• Koninklijke Philips N.V.

U.S. Plaque Modification Devices Market Trends

The U.S. plaque modification devices market is evolving toward more precise, minimally invasive, and image-guided approaches, particularly as clinicians manage increasingly complex and heavily calcified vascular lesions.

· Innovations in compact devices and minimally invasive technologies are facilitating the shift of peripheral interventions from conventional hospital settings to outpatient and office-based locations.

· Recent plaque-modification systems are placing greater emphasis on handling debris produced during atherectomy, enhancing procedural safety and workflow effectiveness.

· The rising adoption of calcium-modification technologies is fueled by the necessity to condition severely calcified arteries before balloon angioplasty or stent insertion.

· Companies are vying with orbital, rotational, directional, laser, and IVL technologies, focusing on accuracy, deliverability, lesion penetration, and procedural effectiveness.

· Moreover, the manufacturers are creating catheter-based systems that integrate plaque extraction with intravascular imaging, allowing for more precise treatment of peripheral lesions.

Collectively, the U.S. market is moving toward technology-driven plaque modification with greater procedural precision, broader outpatient use, and increasing adoption of IVL alongside established atherectomy techniques.

U.S. Plaque Modification Devices Market Analysis

By Product Type

Atherectomy devices are designed to mechanically modify or remove arterial plaque, particularly in complex and calcified lesions, helping prepare vessels for subsequent intervention.

Based on product type, the U.S. plaque modification devices market is categorised into atherectomy devices, thrombectomy devices, chronic total occlusion devices, and embolic protection devices. Atherectomy Devices accounted for the largest share at 48.89% in 2025.

By Application

Plaque modification devices are used to treat calcified and complex coronary lesions, helping modify plaque and prepare vessels for angioplasty or stent placement.

Based on application, the U.S. plaque modification devices market is categorised into Coronary Artery Disease (CAD) and Peripheral Artery Disease (PAD). Coronary Artery Disease is the most dominant segment.

By End-use

Hospitals provide comprehensive infrastructure and specialized vascular-care teams for complex plaque modification procedures, including advanced atherectomy and calcium-modification interventions.

Based on end-use, the U.S. plaque modification devices market is categorized into Hospitals, Ambulatory Surgical Centers, Specialty Centers, and Others. Hospitals are the most dominating segment.